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GGT is an enzyme highly expressed in various tumor cells, which has been extensively employed as a marker for tumor tracking and therapy 23,26,27,28,29

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1 Introduction Multiple myeloma (MM), a hematologic malignancy characterized by clonal proliferation of bone marrow plasma cells, manifests clinically through CRAB criteria: hypercalcemia, renal dysfunction, anemia, and osteolytic lesions ( Ferroptosis, an iron-dependent non-apoptotic cell death driven by excessive lipid peroxidation, was first characterized by Dixon et al., in 2012 through studies on erastin and RAS-selective lethal compounds (Zhang et al., 2022